GPS units usually default to a datum selection of WGS84. However, most USGS topo maps are still keyed to NAD27 unless they are relatively new. Most wilderness area USGS maps that I have seen don't get updated that often (not much changes out there) so they tend to be NAD27. The difference isn't huge, no more than 200 meters, but that can be significant if you are searching for a pointer to a cache. The notes on a topo map will tell you which datum it is based on and you should select that datum in your GPS setup for best accuracy. If you aren't using a map but just storing waypoints in the GPS as you go then the default WGS84 is fine.